Episode
13

GLP-1s and Hormone Therapy: What the Science Says and Why It Matters

with
Dr. Rocio Salas-Whalen
New episodes every wednesday

You’ve heard the headlines. Ozempic, Wegovy, GLP-1s. But what is actually happening inside your body when you take them? In this episode, Tamsen sits back down with triple board-certified endocrinologist Dr. Rocio Salas-Whalen to get real, science-backed answers. They break down how these medications work, why muscle loss is a real risk, and how hormone therapy plays a role in your overall metabolic health.

This conversation goes beyond quick fixes and tackles what sustainable, medically informed weight loss really looks like. It’s about body composition, long-term health, and understanding the emotional impact of a changing body.

They talk about:
  • How GLP-1 medications like Ozempic and Wegovy work in the gut, brain, and pancreas
  • The connection between GLP-1s, visceral fat, and insulin resistance
  • Why you may be losing muscle instead of fat if not monitored properly
  • What "Ozempic butt" really means and how to prevent it
  • The truth about hair loss, protein intake, and rapid weight loss
  • When to combine GLP-1s with hormone therapy and how to approach it safely
  • Why weight loss isn't just physical and the emotional impact many women aren't prepared for

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guest appearing in this episode

Dr. Rocio Salas-Whalen

You’ve heard the headlines. Ozempic, Wegovy, GLP-1s. But what is actually happening inside your body when you take them? In this episode, Tamsen sits back down with triple board-certified endocrinologist Dr. Rocio Salas-Whalen to get real, science-backed answers.

Resources

medical disclaimer:

The information provided in this podcast is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional regarding any medical concerns or treatment options. The views expressed by guests are their own and do not necessarily reflect those of The Tamsen Show.

01:24 - Why Dr. Rocio Salas-Whalen Wanted to Address Misinformation

03:19 - What Is a GLP-1?

05:07 - How do GLP-1s Work in our Bodies?

07:13 - GLP-1s and Anti-Inflammatory Effects

08:22 - The Fascinating Origin of GLP-1s

12:46 - What Is Microdosing and Is It Effective?

14:45 - Oral vs. Injectable GLP-1s: What You Need to Know

16:01 - Why Diet Still Matters on GLP-1s (And What to Eat)

17:20 - Are GLP-1s Really “Vanity” Drugs? A Reframe

18:01 - Combining GLP-1s with Hormone Therapy in Midlife

22:06 - Can You Lose Belly Fat Without Medication or Hormones?

23:06 - The Real Causes of Midlife Weight Gain

25:28 - Why Motivation Often Comes After Weight Loss

26:16 - Can You Come Off GLP-1s Without Gaining the Weight Back?

28:00 - Psychological & Social Side Effects of Weight Loss No One Talks About

29:18 - Excess Skin, Body Image & What Happens After You Lose the Weight

30:07 - The Common Side Effects of GLP-1s

31:58 - The Future of GLP-1s

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